I absolutely loved Mass Effect, except for one aspect... The best armor in the game is Black and PINK! This is the only real factor that I can see as limiting the replay-ability.
So while I can see that allot of thought went into this game's creation. Either they chose to "offend" the sensibilities of a significant portion of their potential player-base. Or they didn't think this aspect through very well. And to make matters worse... they don't seem to be interested in releasing any download-able content to alter the situation.
So while Mass Effect is a very good game. Bioware gets my >