For some reason the system woke up immediately after going to sleep, so I had to put it into sleep mode again, and now after waking up the system is running just fine but the debug led is stuck at 30.
Additionally my logitech g35 headset (plugged into a usb2.0 port) is half-dead after waking up, i.e. the headset and the microphone does work, however none of the buttons including the volume control work after the system woke up, this happens since bios > 1.60. The only way to fix this is by unplugging it and plugging it in again.

Asrock p67 extreme4, 1.90 bios.