<center>New disease under study</center>

In collaboration with other groups at Stanford (esp Klein's group), we have started looking at Collagen folding and misfolding. Collagen is the most common protein in the body and mutations in collagen leads to a very nasty disease called Osteogenesis Imperfecta (or OI for short). In many cases, OI is lethal and leads to miscarriage. However, 1 in 10,000 people have some sort of mutational in collagen. For many, where the mutation is not very serious, it lies unknown and misdiagnosed and leads to brittle bones and other more suble problems. In others, however, mutations lead to more serious morphological disorders (see below).

We are starting to model collagen folding and misfolding in the 1000 series projects. For more info, see http://folding.stanford.edu/cgi-bin/allprojects#1001.