I am not sure what you mean by that, but do not flash a Bios into your board that is not for your board!!

Here is the BIOS's for your board >>>
GIGABYTE - Support&Download - Motherboard - BIOS - GA-EP35C-DS3R (rev. 2.1)

And yes The Rev 2.1 boards are the same as the E boards and yours does support DES Advanced